- 1960 Otis Spann Is the Blues Candid Records
- 1963 Piano Blues Storyville
- 1963 Portrait in Blues Storyville
- 1964 The Blues of Otis Spann Decca
- 1966 Otis Spann's Chicago Blues Testament
- 1967 The Blues Is Where It's At BGO
- 1967 Nobody Knows My Trouble
- 1968 The Bottom of the Blues BGO
- 1968 Raw Blues London
- 1969 The Blues Never Die! Prestige/Original Blues Classics
- 1969 Cracked Spanner Head Decca
- 1969 The Biggest Thing Since Colossus Sony Music Distribution
- 1970 Cryin' Time Vanguard
- 1970 Otis Spann Everest
- 1970 Sweet Giant of the Blues Blues Time
- 1970 The Everlasting Blues Spivey
- 1972 Walking the Blues Candid
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- 1973 Heart Heavy with Trouble
- 1974 Blues Rocks Blues Time
- 1974 Cry Before I Go BluesWay
- 1983 Nobody Knows Chicago Like I Do Charly Records
- 1984 Rarest JSP
- 1991 This Is the Blues Huub
- 1997 Live The Life Testament
- 1999 Best of Vanguard Year's Vanguard
- 2000 Last Call: Live at Boston Tea Party, April 2, ... Mr Cat
- 2003 Heritage Of The Blues/I Wanna Go Home Hightone remasterd - reissue von Otis Spann's Chicago Blues
- 2005 Blues Of Otis Spann/Cracked Spanner Head (2 Originals) Beat Goes On
- 2006 Complete Blue Horizon Sessions Blue Horizon
- 2006 Otis Spann - From The Archives (Digitally Remastered) Essential Media Group
- Half Ain't Been Told Black Cat Record
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- 2002 Various Artists - Colin James presents The Blues Masters
- 2009 U.S. Blues Tour '63
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- Liner notes, THE BLUES NEVER DIE, Prestige Records
- Sheldon Harris, BLUES WHO'S WHO
- Liner notes, PORTRAIT IN BLUES, Storyville Records
- Peter Guralnick, LOST HIGHWAY